Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC003
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-28 16:57
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment Tbl Madopar 250mg 3x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 29 individuals with a value less than 0.62 were subsequently diagnosed with PD. That is, 69.05% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.62 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 14, 'TN': 11, 'TP': 28, 'FP': 19}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 16, 'TN': 11, 'TP': 26, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 15, 'TN': 8, 'TP': 27, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 4.26
timePerCircleCoV 0.15354
timePerCircleSlope -0.0359084
meanError 2.35168
tremorFreq 6.44531
tremorRelPower 35.2587
tremorGyroAmpMean 0.0270122
tremorGyroAmpSlope -0.00271168
tremorGyroAmpCoV 0.446224
tremorCoordAmpMean 0.0765085
tremorCoordAmpSlope 0.00310542
tremorCoordAmpCoV 0.251181
tremorAccAmpMean 0.058647
tremorAccAmpSlope 0.000594871
tremorAccAmpCoV 0.283903
tremorPcRelVar 0.783131
tremorPcX -0.73938
tremorPcY -0.673289

Circle Segment 1

Duration 5.96 s, Accuracy Estimate 2.147 (lower is better)

Circle Segment 2

Duration 4.24 s, Accuracy Estimate 1.853 (lower is better)

Circle Segment 3

Duration 4.24 s, Accuracy Estimate 2.893 (lower is better)

Circle Segment 4

Duration 4.04 s, Accuracy Estimate 2.066 (lower is better)

Circle Segment 5

Duration 4.16 s, Accuracy Estimate 2.128 (lower is better)

Circle Segment 6

Duration 4.6 s, Accuracy Estimate 1.993 (lower is better)

Circle Segment 7

Duration 4.0 s, Accuracy Estimate 2.155 (lower is better)

Circle Segment 8

Duration 3.96 s, Accuracy Estimate 3.295 (lower is better)

Circle Segment 9

Duration 3.72 s, Accuracy Estimate 2.092 (lower is better)

Circle Segment 10

Duration 3.68 s, Accuracy Estimate 2.896 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 14.104
timePerSpiralCoV 0.16274
timePerSpiralSlope -0.0410114
meanError 2.64837
tremorFreq 8.20312
tremorRelPower 51.0636
tremorGyroAmpMean 0.0899915
tremorGyroAmpSlope 0.00113453
tremorGyroAmpCoV 0.445734
tremorCoordAmpMean 0.162528
tremorCoordAmpSlope 0.00171292
tremorCoordAmpCoV 0.352155
tremorAccAmpMean 0.159079
tremorAccAmpSlope 0.000901952
tremorAccAmpCoV 0.430236
tremorPcRelVar 0.875251
tremorPcX -0.419798
tremorPcY 0.907618

Spiral Segment 1

Duration 19.24 s, Accuracy Estimate 2.399 (lower is better)

Spiral Segment 2

Duration 15.84 s, Accuracy Estimate 2.408 (lower is better)

Spiral Segment 3

Duration 12.28 s, Accuracy Estimate 3.168 (lower is better)

Spiral Segment 4

Duration 15.2 s, Accuracy Estimate 2.586 (lower is better)

Spiral Segment 5

Duration 13.92 s, Accuracy Estimate 2.519 (lower is better)

Spiral Segment 6

Duration 14.16 s, Accuracy Estimate 2.595 (lower is better)

Spiral Segment 7

Duration 14.4 s, Accuracy Estimate 2.377 (lower is better)

Spiral Segment 8

Duration 12.08 s, Accuracy Estimate 2.646 (lower is better)

Spiral Segment 9

Duration 11.76 s, Accuracy Estimate 2.887 (lower is better)

Spiral Segment 10

Duration 12.16 s, Accuracy Estimate 2.899 (lower is better)

Elel

eDurationMean 0.498529
eDurationStd 0.071101
eDurationStdnorm 0.142621
eDurationMedian 0.5
eDurationQuartdelta 0.1
eDurationQuartdeltanorm 0.2
eDurationKurt 2.85978
eDurationTrenddiff -0.055
eDurationTrendratio 0.895238
eWidthMean 6.97871
eWidthStd 2.03261
eWidthStdnorm 0.291258
eWidthMedian 6.552
eWidthQuartdelta 2.691
eWidthQuartdeltanorm 0.410714
eWidthKurt 2.50931
eWidthTrenddiff -1.404
eWidthTrendratio 0.809524
eHeightMean 12.3091
eHeightStd 2.12029
eHeightStdnorm 0.172254
eHeightMedian 11.934
eHeightQuartdelta 3.393
eHeightQuartdeltanorm 0.284314
eHeightKurt 2.52283
eHeightTrenddiff -2.34
eHeightTrendratio 0.82906
eAspectMean 0.565429
eAspectStd 0.126903
eAspectStdnorm 0.224437
eAspectMedian 0.549686
eAspectQuartdelta 0.193707
eAspectQuartdeltanorm 0.352396
eAspectKurt 2.40833
eAspectTrenddiff -0.0350877
eAspectTrendratio 0.938272
eSlantMean -0.121671
eSlantStd 0.229533
eSlantStdnorm -1.88651
eSlantMedian -0.0703818
eSlantQuartdelta 0.331481
eSlantQuartdeltanorm -4.70976
eSlantKurt 2.33418
eSlantTrenddiff 0.0124487
eRtopMean 0.707263
eRtopStd 0.130151
eRtopStdnorm 0.184021
eRtopMedian 0.715473
eRtopQuartdelta 0.218717
eRtopQuartdeltanorm 0.305695
eRtopKurt 2.58567
eRtopTrenddiff -0.0263158
eRbotMean 0.95046
eRbotStd 0.365091
eRbotStdnorm 0.38412
eRbotMedian 0.922705
eRbotQuartdelta 0.503905
eRbotQuartdeltanorm 0.546117
eRbotKurt 2.23363
eRbotTrenddiff 0.111111
eRrightMean 0.785606
eRrightStd 0.0917723
eRrightStdnorm 0.116817
eRrightMedian 0.789898
eRrightQuartdelta 0.119643
eRrightQuartdeltanorm 0.151466
eRrightKurt 3.20755
eRrightTrenddiff -0.0228175
eRleftMean 0.461035
eRleftStd 0.126648
eRleftStdnorm 0.274703
eRleftMedian 0.479796
eRleftQuartdelta 0.178108
eRleftQuartdeltanorm 0.371216
eRleftKurt 2.08025
eRleftTrenddiff 0.044733
lDurationMean 0.723182
lDurationStd 0.20424
lDurationStdnorm 0.282418
lDurationMedian 0.695
lDurationQuartdelta 0.30375
lDurationQuartdeltanorm 0.43705
lDurationKurt 2.46296
lDurationTrenddiff -0.2575
lDurationTrendratio 0.689759
lWidthMean 9.33518
lWidthStd 2.55042
lWidthStdnorm 0.273205
lWidthMedian 9.477
lWidthQuartdelta 3.12975
lWidthQuartdeltanorm 0.330247
lWidthKurt 2.41369
lWidthTrenddiff -2.9835
lWidthTrendratio 0.731579
lHeightMean 28.6118
lHeightStd 5.29086
lHeightStdnorm 0.184919
lHeightMedian 29.25
lHeightQuartdelta 4.5045
lHeightQuartdeltanorm 0.154
lHeightKurt 7.62374
lHeightTrenddiff -3.978
lHeightTrendratio 0.871212
lAspectMean 0.330815
lAspectStd 0.0863644
lAspectStdnorm 0.261066
lAspectMedian 0.321951
lAspectQuartdelta 0.103309
lAspectQuartdeltanorm 0.320883
lAspectKurt 7.18226
lAspectTrenddiff -0.053989
lAspectTrendratio 0.848174
lSlantMean 0.0196027
lSlantStd 0.161911
lSlantStdnorm 8.25963
lSlantMedian 0.0125
lSlantQuartdelta 0.180969
lSlantQuartdeltanorm 14.4775
lSlantKurt 4.69977
lSlantTrenddiff -0.00423043
lRtopMean 0.730085
lRtopStd 0.154374
lRtopStdnorm 0.211446
lRtopMedian 0.757143
lRtopQuartdelta 0.222542
lRtopQuartdeltanorm 0.293924
lRtopKurt 2.2468
lRtopTrenddiff 0.057494
lRbotMean 0.672304
lRbotStd 0.341818
lRbotStdnorm 0.508428
lRbotMedian 0.65625
lRbotQuartdelta 0.494574
lRbotQuartdeltanorm 0.753637
lRbotKurt 2.2989
lRbotTrenddiff 0.0743101
lRrightMean 0.770764
lRrightStd 0.150997
lRrightStdnorm 0.195906
lRrightMedian 0.81448
lRrightQuartdelta 0.192943
lRrightQuartdeltanorm 0.236892
lRrightKurt 2.89526
lRrightTrenddiff 0.0243175
lRleftMean 0.38657
lRleftStd 0.139332
lRleftStdnorm 0.360432
lRleftMedian 0.4125
lRleftQuartdelta 0.174575
lRleftQuartdeltanorm 0.423212
lRleftKurt 3.67038
lRleftTrenddiff -0.0587772

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

Elel Segment 16

Elel Segment 17

Elel Segment 18

Elel Segment 19

FITTS Short Modified

meanTouchScore 0.729421
sumTouchScores 12.4002
meanMovementTime 0.992812
numTouches 17
undershootPercentage 0
overshootPercentage 35.2941

FITTS Long Modified

meanTouchScore 0.796166
sumTouchScores 10.3502
meanMovementTime 1.43292
numTouches 13
undershootPercentage 15.3846
overshootPercentage 7.69231

ZigZag

numZigzags 6
timePerZigzagMean 21.9267
timePerZigzagCoV 0.100969
timePerZigzagSlope -0.0237154
meanError 3.51387
tremorFreq 8.30078
tremorRelPower 33.7948
tremorGyroAmpMean 0.0953532
tremorGyroAmpSlope -0.000214383
tremorGyroAmpCoV 0.299171
tremorCoordAmpMean 0.169487
tremorCoordAmpSlope -0.00123985
tremorCoordAmpCoV 0.364204
tremorAccAmpMean 0.142171
tremorAccAmpSlope -0.000466816
tremorAccAmpCoV 0.317024
tremorPcRelVar 0.782634
tremorPcX 0.363212
tremorPcY 0.931707

ZigZag Segment 1

Duration 21.2 s, Accuracy Estimate 4.936 (lower is better)

ZigZag Segment 2

Duration 25.24 s, Accuracy Estimate 2.372 (lower is better)

ZigZag Segment 3

Duration 22.4 s, Accuracy Estimate 4.216 (lower is better)

ZigZag Segment 4

Duration 20.24 s, Accuracy Estimate 3.858 (lower is better)

ZigZag Segment 5

Duration 23.36 s, Accuracy Estimate 3.118 (lower is better)

ZigZag Segment 6

Duration 19.12 s, Accuracy Estimate 2.583 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 17.6667
timePerZigzagCoV 0.113223
timePerZigzagSlope -0.0329919
zigzagHeightMean 72.1303
zigzagHeightCoV 0.173494
zigzagHeightSlope 0.0158163
meanError 0.0415215
tremorFreq 7.12891
tremorRelPower 30.8712
tremorGyroAmpMean 0.056818
tremorGyroAmpSlope -0.00958016
tremorGyroAmpCoV 0.600918
tremorCoordAmpMean 0.135718
tremorCoordAmpSlope -0.000499385
tremorCoordAmpCoV 0.856551
tremorAccAmpMean 0.0842182
tremorAccAmpSlope -0.00859918
tremorAccAmpCoV 0.577192
tremorPcRelVar 0.867878
tremorPcX -0.189107
tremorPcY -0.981956

ZigZag Offset Segment 1

Duration 17.92 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 2

Duration 20.88 s, Accuracy Estimate 0.071 (lower is better)

ZigZag Offset Segment 3

Duration 16.76 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 4

Duration 16.52 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 5

Duration 18.76 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 6

Duration 15.16 s, Accuracy Estimate 0.041 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.62}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.5451115789646006}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8976732619310468}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}